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KMID : 0380020030180020107
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Korean Journal of Biotechnology and Bioengineering
2003 Volume.18 No. 2 p.107 ~ p.110
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Release Characteristics of Biodegradable Polymers for Stent Coating
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Kang Hye-Su
Kim Jin-Seol
Kim Dong-Won
Kang Byung-Chul
Lee Bong-Hee
Kim Beom-Soo
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Abstract
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Biodegradable polymers, poly(lactic-co-glycolic acid) (PLGA), poly(3-hydroxybutyrate) (PHB), and medium chain length polyhydroxyalkanoates (MCL-PHA) containing rose bengal (model drug) were coated onto the surface of stainless steel (stent materials) and their in vitro release characteristics were investigated. Drug release increased with; decreasing PLGA concentration, increasing rose bengal concentration, and Increasing dip-coating duration. The order of drug release from the polymer coating was: PHB > PLGA > MCL-PHA. These results suggest that drug release can be controlled by: changing the concentration and type of polymer, the drug concentration, and the dip-coating duration.
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KEYWORD
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Stent Coating, biodegradable polymer, drug release, PLGA, PHA
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